Accurate ICD-10 coding is crucial for proper medical billing, claim approvals, and effective patient care. The ICD-10 code for acute hypoxic respiratory failure (J96.01) is a life-threatening condition that requires immediate medical attention, making it essential for healthcare providers and medical coders to understand the correct diagnosis coding. Misclassification can lead to claim denials, compliance issues, and potential financial losses.
This comprehensive guide will help you understand the ICD-10 code for acute hypoxic respiratory failure, related billable codes, exclusion criteria, and key documentation tips. Whether you’re a medical coder, healthcare provider, or billing specialist, this blog will ensure you code with accuracy and confidence.
What is Acute Hypoxic Respiratory Failure?
Acute Hypoxic Respiratory Failure (AHRF) occurs when the lungs fail to supply adequate oxygen to the blood, leading to dangerously low oxygen levels (hypoxia). This condition can result from underlying diseases such as pneumonia, sepsis, COPD, COVID-19 complications, or pulmonary edema. Without prompt treatment, AHRF can lead to organ dysfunction, coma, or even death.
Common Causes of Acute Hypoxic Respiratory Failure
- Pneumonia: Infection causes lung inflammation and fluid buildup, impairing oxygen exchange.
- COVID-19 Complications: Severe COVID-19 can cause viral pneumonia and acute respiratory distress syndrome (ARDS).
- Chronic Obstructive Pulmonary Disease (COPD): AHRF can occur in severe cases where lung function is compromised.
- Pulmonary Edema: Fluid accumulation in the lungs restricts oxygen absorption.
- Sepsis: A severe infection can trigger systemic inflammation, leading to lung dysfunction.
ICD-10 Code for Acute Hypoxic Respiratory Failure
The primary ICD-10 code for Acute Hypoxic Respiratory Failure is:
J96.01 – Acute Respiratory Failure with Hypoxia
- Billable? Yes
- Category: Diseases of the Respiratory System
This code is used when a patient experiences acute respiratory failure due to hypoxia, meaning their oxygen saturation levels drop dangerously low and require immediate medical intervention, such as oxygen therapy or mechanical ventilation.
Why is this code important? Proper classification under J96.01 ensures that insurance claims are accurately processed, avoiding denials and ensuring hospitals and healthcare providers receive proper reimbursement.
Related and Billable ICD-10 Codes
In addition to J96.01, there are other billable codes related to Acute Hypoxic Respiratory Failure. Here’s a breakdown:

👉 Each of these codes should be selected based on the patient’s condition and whether the respiratory failure is acute, chronic, or both.
Exclusion Criteria for ICD-10 Coding
While J96.01 is a valid and billable code, it should NOT be used in cases where the respiratory failure is due to the following conditions (Excludes1 rules apply):
- Acute respiratory distress syndrome (J80)
- Cardiorespiratory failure (R09.2)
- Newborn respiratory distress syndrome (P22.0)
- Postprocedural respiratory failure (J95.82-)
- Respiratory arrest (R09.2)
- Newborn respiratory arrest (P28.81)
- Respiratory failure of newborn (P28.5)
If a patient has multiple respiratory conditions, ensure that you code separately for each diagnosis and do not incorrectly bundle them under J96.01. This helps maintain coding accuracy and prevents claim rejections.
Proper Documentation for Accurate Coding
Correct ICD-10 coding for Acute Hypoxic Respiratory Failure depends heavily on thorough medical documentation. To ensure accuracy, healthcare providers should document the following key details:
Key Documentation Requirements:
- Specify the type of respiratory failure: Acute, chronic, or both.
- Identify hypoxia or hypercapnia: J96.01 is specific to hypoxia (low oxygen levels).
- Include underlying causes: Conditions like pneumonia, sepsis, COPD, or COVID-19 must be documented.
- Note the treatment provided: Oxygen therapy, intubation, or mechanical ventilation should be mentioned.
Example Documentation:
“Patient admitted with acute respiratory failure due to pneumonia, presenting with SpO2 at 82%, requiring oxygen therapy. Diagnosed as Acute Hypoxic Respiratory Failure (J96.01).”
Common Clinical Scenarios for Acute Hypoxic Respiratory Failure (J96.01)
To better understand how ICD-10 coding applies in real-world scenarios, let’s look at a few common cases where J96.01 (Acute Respiratory Failure with Hypoxia) is used.
1: COVID-19-Related Acute Hypoxic Respiratory Failure
Patient Case:
A 55-year-old male with COVID-19 develops severe shortness of breath hypoxia (SpO2 at 78%) and requires mechanical ventilation in the ICU. The physician documents acute hypoxic respiratory failure secondary to COVID-19 pneumonia.
ICD-10 Codes Used:
- J96.01 – Acute Respiratory Failure with Hypoxia
- U07.1 – COVID-19
- J12.82 – Pneumonia due to COVID-19
Correct documentation ensures claim approvals and accurate reimbursement for COVID-related care.
2: Acute Hypoxic Respiratory Failure Due to Pneumonia
Patient Case:
A 70-year-old female presents with fever, dyspnea, and low oxygen saturation (SpO2 84%). She is diagnosed with bacterial pneumonia leading to acute hypoxic respiratory failure and is started on oxygen therapy and IV antibiotics.
ICD-10 Codes Used:
- J96.01 – Acute Respiratory Failure with Hypoxia
- J18.9 – Pneumonia, unspecified organism
In this case, documenting pneumonia as the underlying cause is crucial for correct coding.
3: Acute and Chronic Respiratory Failure in a COPD Patient
Patient Case:
A 68-year-old male with chronic obstructive pulmonary disease (COPD) arrives at the ER with severe dyspnea, confusion, and hypoxia. The physician diagnoses acute-on-chronic respiratory failure with hypoxia, and the patient is placed on non-invasive ventilation.
ICD-10 Codes Used:
- J96.21 – Acute and Chronic Respiratory Failure with Hypoxia
- J44.1 – COPD with exacerbation
For patients with both acute and chronic respiratory failure, J96.21 is the correct code instead of J96.01.
Summary
Correctly coding Acute Hypoxic Respiratory Failure (J96.01) is crucial for proper medical billing, reimbursement, and patient care. Healthcare providers must ensure:
- Clear documentation of hypoxia, acute vs. chronic respiratory failure, and underlying causes
- Correct application of billable ICD-10 codes, including J96.01, J96.20, and J96.21
- Avoiding coding exclusions, such as J80 (ARDS) or neonatal respiratory failure codes
By following these best practices, medical coders and healthcare professionals can reduce claim denials, improve coding accuracy, and ensure proper reimbursement for critical respiratory conditions.